Paclitaxel glycolysis

Author: vgch

August undefined, 2024

WebApr 5, 2024 · Overexpression of long non-coding RNA urothelial carcinoma associated 1 causes paclitaxel (Taxol) resistance in colorectal cancer cells by promoting glycolysis. ... Importantly, Taxol-resistant cells had a higher glycolysis rate and upregulated expression of the key glycolysis enzymes hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA) … WebSep 10, 2024 · Dosages of Paclitaxel. Dosage Forms and Strengths. Injectable solution. 6 mg/mL; Dosage Considerations – Should be Given as Follows: Ovarian Cancer. …

Glucose induced-AKT/mTOR activation accelerates glycolysis and …

WebJan 20, 2024 · Paclitaxel-resistant cancer types have been reported to develop more rapid cross-resistance to a variety of unrelated drugs. 65, 66, 67 However, the development of rapid multiplicity and reaction ... WebJan 1, 2024 · The dysregulation of glycolysis regardless of oxygen availability is one of the major characteristics of cancer cells. While the drug resistance of ovarian cancer cells … domani uomo

Knockdown of FOXO6 Inhibits Glycolysis and Reduces Cell …

WebFeb 29, 2024 · Therefore, this study was set out to investigate the effect of FOXO6 on glycolysis and cytotoxicity of paclitaxel in HCC cells and its potential mechanism. The levels of FOXO6 mRNA and protein were detected by qRT-PCR and Western blot, respectively. In addition, paclitaxel-resistant cell lines of HCC cells were established, whose activity was ... WebIntegrated with the above studies, we reasonably speculated that FOXO6 may be related to paclitaxel resistance and glycolysis in HCC cells. Therefore, the biological role and mechanism of FOXO6 in paclitaxel resistance of HCC cells were investigated in the present study, aiming to provide new molecular directions and preventing resistance to ... WebOct 8, 2024 · GSEA showed the upregulation of glycolysis-related genes (hallmark of glycolysis) in the ALDH-high spheroid cells (Figure 6A). In fact, ALDH-high cells displayed higher levels of the extracellular acidification rate (ECAR) than ALDH-low cells ( Figures 6 B and S4 A) and the treatment with disulfiram reduced ECAR ( Figures 6 C and S4 B ... domani tv sera

Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis …

Paclitaxel glycolysis

Circ_0000231 promotes paclitaxel resistance in ovarian cancer by ...

WebAug 1, 2024 · Treatment with AVB-500 + paclitaxel decreased AKT signaling, which resulted in a decrease in basal glycolysis. Finally, treatment with AVB-500 + paclitaxel decreased multiple glycolytic metabolites, including fructose-1,6-bisphosphate (p=0.002), 3-phosphoglyceric acid (p=0.014), phosphoenolpyruvate (p=0.013), and lactate (p=0.024) … WebSep 11, 2013 · In addition, targeting metabolism as a strategy to overcome drug resistance was investigated using specific metabolic inhibitors. Inhibition of glycolysis and oxidative …

Did you know?

WebMay 27, 2024 · Increased glycolysis in tumor cells is frequently associated with drug resistance. Overexpression of glucose transporter-1 (GLUT1) promotes the Warburg effect and mediates chemoresistance in various cancers. Aberrant GLUT1 expression is considered as an essential early step in the development of endometrial cancer (EC). … WebNational Center for Biotechnology Information

WebDec 10, 2024 · Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available. ... G. et al. 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and ... WebFeb 29, 2024 · Therefore, this study was set out to investigate the effect of FOXO6 on glycolysis and cytotoxicity of paclitaxel in HCC cells and its potential mechanism. The …

WebIntegrated with the above studies, we reasonably speculated that FOXO6 may be related to paclitaxel resistance and glycolysis in HCC cells. Therefore, the biological role and … WebSep 11, 2013 · In addition, targeting metabolism as a strategy to overcome drug resistance was investigated using specific metabolic inhibitors. Inhibition of glycolysis and oxidative phosphorylation by 2-deoxyglucose and malonate, respectively, potentiated the effects of paclitaxel on nonresistant lung adenocarcinoma cells but not paclitaxel-resistant cells.

WebAug 2, 2024 · The inhibitory effects of paclitaxel and doxorubicin were significantly enhanced when glucose concentration was decreased in the culture medium, requiring 1000-fold lesser concentration to achieve a similar degree of inhibition to that seen in glucose-containing medium. ... 2-DG is a D-glucose analogue which inhibits glycolysis …

WebJan 24, 2024 · Paclitaxel (PTX) resistance contributes to mortality in epithelial ovarian cancer (EOC). Aerobic glycolysis is elevated in the tumor environment and may influence … domani tuWebMay 14, 2024 · Although mitochondrial respiration is the primary pathway to obtain ATP in most cells, aerobic glycolysis is also essential for cancer cells as well as other highly proliferating cell types (e.g ... domani tv rai 1http://cls.hznu.edu.cn/c/2024-11-06/2474074.shtml domani torno karaokeWebproducing ATP by glycolysis. • Lactate dehydrogenase allows fermentation to convert NADH to NAD+, which is needed for glycolysis to continue making ATP. 1 point. 1.C. ... Based on … pvd drug classWebNov 6, 2024 · Tissue-specific study across the stem of Taxus media identifies a phloem-specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis. Plant J. 103(1):95-110. Plant J. 103(1):95-110. pvd-i07 amazonWebMar 15, 2024 · Paclitaxel (PTX) resistance contributes to mortality in epithelial ovarian cancer (EOC). Aerobic glycolysis is elevated in the tumor environment and may influence … pvd goalsWebGAS6-AXL Inhibition by AVB-500 Overcomes Resistance to Paclitaxel in Endometrial Cancer by Decreasing Tumor Cell Glycolysis. Shaina F. Bruce, Kevin Cho, Hollie Noia, Elena Lomonosova, Elizabeth C. Stock, Alyssa Oplt, Barbara Blachut, ... domani urbinati