Gata3 and breast cancer
WebJun 1, 2009 · GATA3 expression inhibits breast tumor outgrowth and spontaneous lung metastasis. To test the hypothesis that GATA3 can negatively regulate the ability of …
Gata3 and breast cancer
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WebApr 14, 2024 · C-X-C motif chemokine ligand 1 (CXCL1) is a member of the CXC chemokine subfamily and a ligand for CXCR2. Its main function in the immune system is the … WebTriple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. ... GATA3 had moderate sensitivity (30.4%) and excellent specificity (98.7%) and misclassified only 2/152 LA (1.3%). GCDFP15 had a moderate sensitivity (20.8%) and excellent ...
WebGATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 … WebApr 8, 2024 · Breast cancer is a heterogeneous disease with different molecular subtypes. Breast cancer is the second leading cause of mortality in woman due to rapid metastasis and disease recurrence. Precision medicine remains an essential source to lower the off-target toxicities of chemotherapeutic agents and maximize the patient benefits. This is a …
WebSep 17, 2024 · GATA3 mutations are known to play an important role in breast cancer progression. The exact role and mechanisms of these mutations remain controversial as some studies suggest a relation to breast tumor growth, while others suggest a relation to longer survival. GATA3 germline mutations are not well studied in breast cancer. WebThis real-world cohort analysis assessed the efficacy of alpelisib and endocrine treatment (ET) combinations in a post-everolimus setting. Thirteen women who started alpelisib and ET at standard doses between 2024 and 2024 for advanced breast cancer (ABC), after undergoing CDK4/6i and everolimus treatment, were eligible for the study entry. The …
WebStudies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding …
WebNov 12, 2024 · GATA3 has been shown to be associated with the luminal subtype of breast cancer, whereas 88% of estrogen receptor (ER)-negative tumors retained GATA3 expression [ 15 ]. Its expression rate in triple-negative cancer ranged from 20.16 to 48% [ 16, 17] in contrast to 74.6% in apocrine type triple-negative breast cancer [ 18 ]. overclock 10900kIn the TCGA-BRCA cohort, tumors of 975/1085 female patients were evaluated for somatic mutations. Among these patients, a total of 103 different GATA3 mutations were identified in 138 patients (14.15%). Insertions constituted the largest type of mutations (50.5%), followed by deletions (29.1%) and substitutions … See more The median overall survival was 10.80 ± 0.7 years (11.69 ± 3.63 and 10.61 ± 2.19 years in patients without GATA3 mutation compared … See more To gain an insight into the functionality of the DEGs between normal and tumor (mutant and non-mutant) samples, gene set enrichment analysis was performed using the Metascape … See more According to the TCGA expression data, GATA3 expression level was higher in GATA3-mutant (log FC = 2.78, p = 4.38E−34 in all patients and log FC = 2.66, p = 2.07E−57 in ER … See more To gain a better understanding of the biological relationships between breast cancer-related genes, the genes that share the same GO term related to breast cancer were … See more ralph bunche 1950 nobel peace prizeWebNov 20, 2014 · GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in … ralph bunche library stateWeb21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the … overclock 1650 kawpowWebNov 12, 2024 · GATA3 has been shown to be associated with the luminal subtype of breast cancer, whereas 88% of estrogen receptor (ER)-negative tumors retained GATA3 … overclock 11400fWebThis real-world cohort analysis assessed the efficacy of alpelisib and endocrine treatment (ET) combinations in a post-everolimus setting. Thirteen women who started alpelisib … ralph bunche high school king george vaWebMar 4, 2024 · GATA3 acts as a suppressor in breast cancer metastasis, for it can mediate the reversal of epithelial-mesenchymal transition and thus promotes epithelial differentiation of invasive cancer cells [ 18, 19 ]. Further, GATA3 is also involved in the development of nervous system [ 20 ], kidney [ 21 ], and skin [ 22 ]. overclock 12950hx