Chromatin disease
WebNov 20, 2014 · It has been used widely to detect open chromatin in normal and diseased cells [ 86, 91, 94, 95 ], to associate specific chromatin states with known sequence variants of disease susceptibility [ 91] or allele-specific signatures [ 96 ], and to decipher the effects of TF binding to chromatin structure [ 97, 98 ]. WebHelp to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE). Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not …
Chromatin disease
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WebThe dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different … WebApr 11, 2024 · The level of transcription factor activity and chromatin accessibility at this early time point differentiated cases by disease severity, even before actual transcription …
WebMar 20, 2024 · Chromatin remodeling and histone modifications play essential roles in heart development and disease by reprogramming gene expression under different … WebSep 16, 2013 · Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic islets.
WebApr 13, 2024 · The role of chromatin accessibility in the promotion or inhibition of kidney repair and regeneration has important implications for designing therapies for acute and chronic kidney disease and... WebChromatin accessibility has a fundamental role in a wide range of biological processes including gene regulation and DNA repair. While the dogma open chromatin = transcribed genes still stands, there is still much unexplored in understanding which molecular mechanisms regulate chromatin accessibility, which are inherited, and which are failing …
WebSep 2, 2024 · They discuss how three-dimensional (3D) organization of chromatin relates to gene expression, development and disease, and consider its effect on genome evolution. Boyan Bonev Giacomo Cavalli
WebMar 17, 2024 · Facing a deteriorating natural environment and an increasing serious food crisis, bioengineering-based breeding is increasing in importance. To defend against pathogen infection, plants have evolved multiple defense mechanisms, including pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered … alberto constanteWebHere, we discuss new findings, which have linked chromatin conformation with development, differentiation and diseases and hypothesized on various models while integrating all recent findings on how chromatin architecture affects gene expression during … Here, we discuss new findings, which have linked chromatin conformation with … Here, we discuss new findings, which have linked chromatin conformation with … Loop is the open research network that increases the discoverability and impact … alberto consuegraWebIt is now well established that the interplay of sequence-specific DNA binding proteins with chromatin components and the subsequent expression of differential genetic programs is the major determinant of developmental decisions. The last years have seen an explosion of basic research that has signi … alberto con putinWebFeb 24, 2024 · Identification of regulatory elements in tubular cells. a Schematic of strategy to functionally annotate disease-associated variants with 1D and 3D epigenetic landscapes.b ChromHMM-based chromatin states in tubular cells. Each row corresponds to a different state, and each column corresponds to a different mark for three histone … alberto conteWebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be … alberto consuegra grangeralbertoconte242 gmail.comWebSep 4, 2024 · Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic... alberto cont